Instantaneous Wave Free Ratio for the Assessment of Intermediate Left Main Coronary Artery Stenosis: Correlations with FFR/IVUS and Prognostic Implications: The iLITRO – EPIC07 Study
Oriol Rodriguez-Leor, José María de la Torre Hernandez, Tamara García Camarero, Bruno García del Blanco, Ramón Lopez-Palop, Eduard Fernandez-Nofrerias, Carlos Cuellas Ramón, Marcelo Jiménez-Kockar, Jesús Jimenez-Mazuecos, Francisco Fernández Salinas, Josep Gomez-Lara, Salvatore Brugaletta, Fernando Alfonso, Ricardo Palma, Antonio E. Gómez-Menchero, Raúl Millán, David Tejada Ponce, José Antonio Linares Vicente, Soledad Ojeda, Eduardo Pinar, Estefanía Fernández-Peregrina, Francisco J. Morales-Ponce, Ana Belén Cid-Álvarez, Juan Carlos Rama-Merchan, Eduardo Molina Navarro, Javier Escaned and Armando Pérez de Prado.
Background: There is little information available on agreement between fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) in non-left main coronary artery (LMCA) intermediate stenosis. Besides, several meta-analyses support the use of FFR to guide LMCA revascularization, but limited information is available on iFR in this setting. Our aims were to establish the concordance between FFR and iFR in intermediate LMCA lesions, to evaluate with intravascular ultrasound (IVUS) in cases of FFR/iFR discordance, and to prospectively validate the safety of deferring revascularization based on a hybrid decision-making strategy combining iFR and IVUS.